Tribute to Koanic

This study shows that he was right about basically everything. Here’s the full discussion section (emphases added where I actually understood something after reading it):

In this work, we describe relationships between Neanderthal-derived genetic variation and co-localized cranial and brain morphology in modern humans. The results show that greater NeanderScore is associated with more Neanderthal-like skull shape (corresponding to published shape differences between modern humans and Neanderthals as documented in fossil samples2 and shown in Fig. 1), as well as regional changes in brain morphology underlying these skull changes, specifically in the IPS and visual cortex. This work not only offers an unprecedented window into structure of the Neanderthal brain, but also characterizes the contributions of admixture with H. neanderthalensis to the evolution of the modern human brain.

Figure 1: NeanderScore related skull shape changes. Associations between skull morphology and percentage of Neanderthal-derived SNPs (NeanderScore) in modern humans (Left), compared to differences between Neanderthal and modern human skulls (Right). Left panel shows regions with morphological changes, measured in vivo, related to NeanderScore and overlaid on the average skull of all 146 participants. Warm colors represent areas for which NeanderScore correlated with skull expansion (p < 0.05, FWE-corrected). There were no findings in the opposite direction. Right panel depicts previously published shape differences between Neanderthals and modern humans, from archeological samples, overlaid on a modern human skull. Red regions represent skull expansion in Neanderthals relative to modern humans; green represents contraction, adapted by permission from Macmillian Publishers Ltd: Nature2, © 2001. Note the convergence of in vivo and archeological data in occipito-parieto-temporal regions (arrows).

In examining the associations of NeanderScore with skull shape, it is important to note that the topology of the identified occipito-parieto-temporal patch associated with NeanderScore specifically recapitulates the pattern of expansion in Neanderthal relative to anatomically modern human skulls previously reported from fossil remains (Fig. 1, right)2. This finding provides crucial validation of the NeanderScore measurement and suggests that even in the context of the modern H. sapiens genome, Neanderthal genetic variation is associated with patterns of skull dimensions that mirror known Neanderthal phenotypes.

Additional validation of the NeanderScore metric lies in its comparison with other reports characterizing Neanderthal-derived genetic contributions to modern humans. The coefficient of variation (i.e., the relative standard deviation, independent of the mean and comparable across measures) of the NeanderScore metric is consistent with previous published studies5 that were performed with a different goal: prior studies, unlike ours, sought to test for differences in admixture across populations, and have, therefore, calculated the proportion of the entire genome that was derived from Neanderthals. In those studies, approximately 1.15% of the entire genome of persons of European decent was found to be derived from Neanderthals (standard deviation = 0.08)5. Inherently, that approach and the present one capture related though different characteristics of Neanderthal-derived genetic information and the means (and therefore the standard deviations as well) of these differently derived measures are not the same. Importantly, however, the coefficient of variation in previous studies was also 0.070,5 identical to the coefficient of variation reported here, providing further validity to the NeanderScore measure.

In determining NeanderScore related changes in brain morphology, we found two significant cortical regions, the IPS and primary visual cortex, which both directly underlie the region of skull shape associations. The IPS, though present throughout highly gyrified modern primates28, has been theorized to have undergone substantial evolutionary expansion in hominids, with cross-species functional neuroimaging demonstrating unique visuospatial processing characteristics in modern humans relative to rhesus monkeys32. Additionally, cranial vault analyses of fossil skulls have suggested differences in the parietal lobes of Neanderthals1415, and the intraparietal sulcal region in particular has been hypothesized to be a focus for some of these differences33. Moreover, the fact that the IPS is particularly critical for tool manipulation in modern humans34 makes this finding even more intriguing in view of continued debate over the nature and development of Neanderthal tool use35.

In other words, neanderthals were (/are) better tool users than modern humans. Since Woodley is working on a measure for “technology use IQ” which is, like visuospatial ability, significantly detached from g and basically equivalent to brain masculinization, we should expect all of these things to end up correlating with neanderthal admixture, Asperger’s, and the engineering personality. Of course, we could have figured this out from looking at the animal bones strewn throughout the average computer programmer’s work area, or by correlating math aptitude with the speed at which one’s ear and back hair grow, but then we would have to give up the blank slate fantasy that says black men would be just as good at math if only young white women would have unprotected sex with them.

Figure 2: NeanderScore related brain changes in the intraparietal sulcus. Structural variation of the intraparietal sulcus (IPS) related to percentage of Neanderthal-derived SNPs (NeanderScore). Left and middle show lateral and posterior views of the right IPS on the average brain surface, illustrating the anatomical convergence of the associations of NeanderScore with greater sulcal depth (orange; p < 0.05 FWE-corrected), gray matter volume (blue; p < 0.005), and white matter volume (yellow; p < 0.005). Right shows a coronal slice (y = −72 mm) through the IPS where there was a sulcal depth difference of 4 mm between the 30 individuals with highest (blue line) and lowest (red line) NeanderScore. Findings are depicted on the average brain of all 221 individuals included in the study and underlie the maximal skull findings shown in Fig. 1 (arrows).

The other brain region revealed to have significant associations with NeanderScore was primary visual cortex. This cortical region is responsible for the first steps in processing of visual information in the mammalian cortex and feeds into later brain regions in the ventral and dorsal visual processing streams (which differentially subserve object recognition and visuospatial object location, respectively)36, with the IPS playing a prominent role in the latter. Though the functioning of the primary visual system is relatively conserved in primates, the size of primary visual cortex in modern humans is smaller than would be expected from brain volume37. Our data not only suggest that this may be less the case in Neanderthals, but also are consistent with cranial remains showing more prominent visual systems in Neanderthals than in modern humans15.

It should be noted that we did not find associations of NeanderScore with smaller frontotemporal volumes38 or shortened anterior extension of the temporal lobes13, as might have been hypothesized from previous cranial analyses of H. neanderthalensis, suggesting either that these particular phenotypes, if accurate, are not driven by the allelic variation captured by the NeanderScore measurement, or that such effects are more directly influenced by any of the myriad factors that establish the genetic and biological context of this modern cohort. Additionally, some of these phenotypes may be only partially modulated by genotypic factors inherited from Neanderthals, with an effect too small to be observed in our sample. In contrast, the effect sizes we observed here for the associations of NeanderScore with the skull and brain measures were moderate (average Cohen’s d = 0.58) but appropriate for the sample sizes used.

Figure 3: NeanderScore related brain changes in the primary visual cortex. Associations between local gyrification index, gray matter volume, and NeanderScore in visual cortex. Medial view of the primary visual cortex showing areas where NeanderScore was significantly associated with local gyrification index (red; p < 0.05 FWE-corrected) and with gray matter volume (yellow; p < 0.005).

The analyses reported here were restricted to a sample of individuals of European descent. It is known that the degree of admixture is variable in different modern populations. For example, East Asian populations have been found to have a larger portion of the genome derived from Neanderthals than European populations (up to 20% more), though the admixed regions of the genome are not necessarily overlapping5. This raises the possibility that the findings reported here may not translate to other populations, where Neanderthal introgression may involve other genomic regions that may be functional in different ways. As large neuroimaging and genetic data from different populations become available, future work could investigate this possibility by performing similar analyses in different populations, including using African populations with minimal Neanderthal admixture as potential “null hypothesis” groups.

Figure 5: QQ plot showing observed versus expected −log10 (p values) for association at all Neanderthal-derived loci of the shared variance of all Neanderthal-associated brain measures.

Finally, our analyses of the relationship of our findings to specific Neanderthal-derived gene variants, revealed a single 53 kb LD block that was significantly associated with the shared variance of the identified Neanderthal-derived brain and skull changes and that encodes for the gene GPR26. In line with our primary hypothesis for this analysis, that such genetic influences would be found in genes preferentially expressed in the human brain, GPR26 in fact encodes a G-protein coupled receptor subtype that is preferentially expressed in the brain29. Interestingly, in human post-mortem brains samples, expression of GPR26 peaks perinatally39, when the visual system is first challenged, indicating that it may play a role in development of the human visual system. Mouse models also show this gene to impact both affective and energy homeostatic functions4041. Additionally, this G-protein-coupled receptor has been shown to form oligomers with the 5-HT1a receptor42, perhaps providing a putative mechanism underlying the Neanderthal-related brain changes found here. Although the nature of the influence of this region on modern and archaic human nervous systems is uncertain, a possible link between brain energy regulation, neurodevelopment and mature structure may merit further investigation.

Because the NeanderScore measure employed here is, itself, polygenic, it is likely that the genetic contributions to skull and brain morphology we observed involve a number of different genetic loci. Nonetheless, our exploratory post-hoc genome-wide analysis of the shared variance of these findings identified only a single significant region. It is unlikely that this single locus, the LD block on chromosome 10, fully explains the brain and skull findings, and in fact, the Manhattan plot in Fig. 4 suggests that multiple other regions that do not meet strict Bonferroni corrections may represent some degree of true signal. Our modest sample size may have been underpowered to identify these additional signals. As larger datasets containing both genotype and neuroimaging data of brain and skull become available, future work will likely uncover additional genetic regions contributing to these findings.

Taken together, the associations between Neanderthal sequence variation and co-localized skull and brain morphology in modern humans engender an enduring, living footprint of H. neanderthalensis – a residual echo of shared, intimate history with a fallen lineage close to our own.

One might use the phrase “living ghosts” if one were throwing a bone to one’s source of inspiration.

To the extent that characterization of Neanderthal variation in present-day people can provide insights into archaic human phenotypes, this work can form the basis of future studies aimed at a more thorough understanding of Neanderthal biology. By the same token, we suggest that Neanderthal gene flow into modern humans is not only of evolutionary interest, but may also be functional in the living H. sapiens brain, revealing novel genetic influences on neurodevelopment of the visuospatial system upon which a fuller account of molecular mechanisms of IPS-driven normative mental functions, such as visuospatial integration and tool manipulation, can be built. This, in turn, may inform models of IPS-associated cognitive disability as seen in select developmental and neurological disorders43,44,45,46.

I guess that last bit will have to be forgiven, since you can only get funding for “disorders” these days. At least Hitler, for all his faults, changed his mind about exterminating neanderthals when he was shown that he needed them to achieve any of his goals…I don’t expect similar self-reflection from the sorts of people who want to be moral authorities but without the responsibilities of leadership. I.e. the social perks of being a priest with the social unaccountability of a shaman.

H/T to Ken for seeing the study, who further notes:

>Additionally, this G-protein-coupled receptor has been shown to form oligomers with the 5-HT1a receptor42, perhaps providing a putative mechanism underlying the Neanderthal-related brain changes found here.

“Hot damn! Christmas came early. 5-HT is serotonin. Reinforces the neurotransmitter-lobe associations.”

I’m pretty sure that association between occ and serotonin was a guess, and I can’t remember if it was one of mine or one of Ken’s, but I’m going to take credit.

All of this, taken together, bodes ill for the Horatio project:

About Aeoli Pera

Maybe do this later?
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13 Responses to Tribute to Koanic

  1. Obadiah says:

    >By the same token, we suggest that Neanderthal gene flow into modern humans is not only of evolutionary interest, but may also be functional in the living H. sapiens brain

    It’s more of a “tribute to Tex and rdos”. Koanic just followed the implications through and developed them brilliantly.

    • Aeoli Pera says:

      Edenic physiognomy is all Koanic.

      • Obadiah says:

        Yeah but brining the basic premise of ‘Neanderthal gene flow into modern humans is not only of evolutionary interest, but may also be functional in the living H. sapiens brain’ into the idea-space is tex/rdos, and that’s all the detail this poast gets into.

        Basically the poast is not worthy of being a tribute to Koanic. lol

        • Boneflour says:

          The neanderscore thing at the beginning of the poast, the part where they talk about a signature neanderthal brain size and skull shape?…

          Looks a lot like the occipital bun thing in the Koanic’s Mohawk skull reading guide.

          Lotta detail about increased brain mass in key areas and skull bumps that happen to match Koanic predictions/systems.

          There’s a lot of work in between raising the basic premise of genetic admixture, and making a bunch of specific measurable predictions.

          I remember Tex talking about certain physical characteristics and personality bits but not skull shape. So I would credit Koanic for this one. But I could be wrong, it’s been a long time!

        • bicebicebice says:


  2. bicebicebice says:

    “East Asian populations have been found to have a larger portion of the genome derived from Neanderthals than European populations (up to 20% more)” with the absolute state of the west, a stable higher average neanderboonscore pop is better than a few random genious retards who won’t be able to work together on anything-besides you can just entice those people to work for you. only very stable autistic downs syndrome cavementhrowback savants have the patience to manufacture everything on the planet then go gome sleep and do it all over again the next day, living on nothing but a bowl of rice and praise from someone who they recognize as genetically better than them thus the praise is actually worth something unlike say 6gorillion zogbucks neatly stacked in a briefcase.

    looks like another win for CHYNA and koanic:

    “Life is an MMO
    Posted on October 10, 2011 by Koanic
    I’ve added a new line to the “I am an Aquatic Ape cyborg” koan in the “Who am I?” set. It now reads:

    “I am an Aquatic Ape cyborg. (Life is an MMO)”

    MMO is short for MMORPG, which stands for Massive Multiplayer Online Roleplaying Game. This koan won’t mean much to you if you’ve never played an MMO. I recommend you buy the current coolest MMO, Rift, and get acquainted.

    The thing about MMO’s is, they’re easy and they provide constant progression and exploration. You run around talking to people and doing things for them, and become increasingly more badass in the process, plus you save the world/universe/whatever. Every incremental step of progress is a reward. You can’t skip steps, but once a step is completed there’s no reward in going back to old activities.

    So how does this relate to life? And more specifically, to Koanic Soul?

    Well, since I’ve started mixing praying tongues in with cycling the other koans, everything has become relaxing and easy. Exactly like an MMO. The path of life is clearly defined, and you just do the steps to succeed. It’s that simple. So you enjoy the ride.

    This koan reminds me to enjoy the sequential progress of life the same way I enjoy playing an MMO, and to take it with the same level of seriousness.

    I feel like this is profound and I should write more about it, but there’s nothing else to say.”

    “Communist joke, and tongues
    Posted on October 10, 2011 by Koanic
    My girlfriend is a member of the Chinese Communist Party.

    This morning she said, “I never tell people I’m a Communist. I only tell them when they give us free lunch or free travel.”

    I pointed out that free stuff was the essence of communism.

    She said, “See? I’m the real one.””

    come home white man itz time to stop the cardio routine its getting old and wearing you out, too

  3. Big says:

    In 2012, you posted the “Red Pill Sourcelist”. I like the organizational idea, of getting all the mind-changing stuff into one list. I’m curious what additions you’d have to it in the present. (Although that might be a big list)

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